PDB entry 2r6n

View 2r6n on RCSB PDB site
Description: Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K
Class: hydrolase
Keywords: covalent bond to inhibitor, Disease mutation, Glycoprotein, Hydrolase, Lysosome, Protease, Thiol protease, Zymogen
Deposited on 2007-09-06, released 2007-11-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin k
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSK, CTSO, CTSO2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2r6na_
  • Heterogens: CKE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r6nA (A:)
grapdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvs
endgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegne
kalkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhw
iiknswgenwgnkgyilmarnknnacgianlasfpkm

    Sequence, based on observed residues (ATOM records): (download) 
    >2r6nA (A:)
rapdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvse
ndgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegnek
alkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwi
iknswgenwgnkgyilmarnknnacgianlasfpkm