PDB entry 2r5q

View 2r5q on RCSB PDB site
Description: Crystal Structure Analysis of HIV-1 Subtype C Protease Complexed with Nelfinavir
Class: hydrolase
Keywords: HIV-1 subtype C, Aspartyl protease, Hydrolase, Protease, VIRAL PROTEIN
Deposited on 2007-09-04, released 2007-11-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.253
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protease
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q50CM2 (0-98)
      • engineered (6)
      • engineered (32)
      • conflict (36)
      • engineered (62)
    Domains in SCOPe 2.06: d2r5qa_
  • Chain 'B':
    Compound: Protease
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q50CM2 (0-98)
      • engineered (6)
      • engineered (32)
      • conflict (36)
      • engineered (62)
    Domains in SCOPe 2.06: d2r5qb_
  • Chain 'C':
    Compound: Protease
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q50CM2 (0-98)
      • engineered (6)
      • engineered (32)
      • conflict (36)
      • engineered (62)
    Domains in SCOPe 2.06: d2r5qc_
  • Chain 'D':
    Compound: Protease
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q50CM2 (0-98)
      • engineered (6)
      • engineered (32)
      • conflict (36)
      • engineered (62)
    Domains in SCOPe 2.06: d2r5qd_
  • Heterogens: 1UN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2r5qA (A:)
pqitlwkrplvsikvggqikealldtgaddtvieeialpgrwkpkmiggiggfikvrqyd
qiiieicgkkaigtvlvgptpvniigrnmltqlgctlnf

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2r5qB (B:)
pqitlwkrplvsikvggqikealldtgaddtvieeialpgrwkpkmiggiggfikvrqyd
qiiieicgkkaigtvlvgptpvniigrnmltqlgctlnf

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2r5qC (C:)
pqitlwkrplvsikvggqikealldtgaddtvieeialpgrwkpkmiggiggfikvrqyd
qiiieicgkkaigtvlvgptpvniigrnmltqlgctlnf

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2r5qD (D:)
pqitlwkrplvsikvggqikealldtgaddtvieeialpgrwkpkmiggiggfikvrqyd
qiiieicgkkaigtvlvgptpvniigrnmltqlgctlnf