PDB entry 2r4b

View 2r4b on RCSB PDB site
Description: ErbB4 kinase domain complexed with a thienopyrimidine inhibitor
Class: transferase
Keywords: Erb, kinase, ATP-binding, Glycoprotein, Membrane, Nucleotide-binding, Phosphorylation, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2007-08-31, released 2008-03-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.209
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2r4ba_
  • Chain 'B':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2r4bb_
  • Heterogens: GW7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2r4bA (A:)
mkkghhhhhhgletelvepltpsgtapnqaqlrilketelkrvkvlgsgafgtvykgiwv
pegetvkipvaikilnettgpkanvefmdealimasmdhphlvrllgvclsptiqlvtql
mphgclleyvhehkdnigsqlllnwcvqiakgmmyleerrlvhrdlaarnvlvkspnhvk
itdfglarllegdekeynadggkmpikwmalecihyrkfthqsdvwsygvtiwelmtfgg
kpydgiptreipdllekgerlpqppictidvymvmvkcwmidadsrpkfkelaaefsrma
rdpqrylviqgddrmklpspn

    Sequence, based on observed residues (ATOM records): (download) 
    >2r4bA (A:)
lvepltpsgtapnqaqlrilketelkrvkvlgsgafgtvykgiwvpegetvkipvaikil
nanvefmdealimasmdhphlvrllgvclsptiqlvtqlmphgclleyvhehkdnigsql
llnwcvqiakgmmyleerrlvhrdlaarnvlvkspnhvkitdfglarllegdekeynadg
gkmpikwmalecihyrkfthqsdvwsygvtiwelmtfggkpydgiptreipdllekgerl
pqppictidvymvmvkcwmidadsrpkfkelaaefsrmardpqrylviqgdd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2r4bB (B:)
mkkghhhhhhgletelvepltpsgtapnqaqlrilketelkrvkvlgsgafgtvykgiwv
pegetvkipvaikilnettgpkanvefmdealimasmdhphlvrllgvclsptiqlvtql
mphgclleyvhehkdnigsqlllnwcvqiakgmmyleerrlvhrdlaarnvlvkspnhvk
itdfglarllegdekeynadggkmpikwmalecihyrkfthqsdvwsygvtiwelmtfgg
kpydgiptreipdllekgerlpqppictidvymvmvkcwmidadsrpkfkelaaefsrma
rdpqrylviqgddrmklpspn

    Sequence, based on observed residues (ATOM records): (download) 
    >2r4bB (B:)
lvepltpsgtapnqaqlrilketelkrvkvlgsgafgtvykgiwvpegetvkipvaikil
anvefmdealimasmdhphlvrllgvclsptiqlvtqlmphgclleyvhehkdnigsqll
lnwcvqiakgmmyleerrlvhrdlaarnvlvkspnhvkitdfglarllegdekeynadgg
kmpikwmalecihyrkfthqsdvwsygvtiwelmtfggkpydgiptreipdllekgerlp
qppictidvymvmvkcwmidadsrpkfkelaaefsrmardpqrylviqgdd