PDB entry 2qur

View 2qur on RCSB PDB site
Description: Crystal Structure of F327A/K285P Mutant of cAMP-dependent Protein Kinase
Class: signaling protein, transferase
Keywords: crystal structure, cAMP-dependent protein kinase, F327A/K285P mutant, isoform specific regulation, AGC-specific insert, SIGNALING PROTEIN, TRANSFERASE
Deposited on 2007-08-06, released 2008-07-29
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-06-16, with a file datestamp of 2009-06-12.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.212
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Mus musculus [TaxId:10090]
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05132 (Start-349)
      • modified residue (196)
      • engineered (284)
      • engineered (326)
      • modified residue (337)
    Domains in SCOPe 2.02: d2qura_
  • Chain 'B':
    Compound: 20-mer fragment from cAMP-dependent protein kinase inhibitor alpha
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ADP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qurA (A:)
gnaaaakkgseqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlv
khkesgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvaggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlpngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnaddyeeeeirvsinekcgkeftef

    Sequence, based on observed residues (ATOM records): (download) 
    >2qurA (A:)
eqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhya
mkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfs
hlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakr
vkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyeki
vsgkvrfpshfssdlkdllrnllqvdltkrfgnlpngvndiknhkwfattdwiaiyqrkv
eapfipkfkgpgdtsnaddyeeeeirvsinekcgkeftef

  • Chain 'B':
    No sequence available.