PDB entry 2qse

View 2qse on RCSB PDB site
Description: Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain complexed with Burned Meat Compound 4-OH-PhIP
Class: transcription
Keywords: Protein-Ligand Complex, DNA-binding, Lipid-binding, Metal-binding, Nucleus, Phosphorylation, Receptor, Steroid-binding, Transcription, Transcription regulation, Zinc-finger
Deposited on 2007-07-30, released 2008-03-18
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.171
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (240)
    Domains in SCOPe 2.01: d2qsea_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (240)
    Domains in SCOPe 2.01: d2qseb_
  • Chain 'C':
    Compound: nuclear receptor coactivator 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: nuclear receptor coactivator 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 1HP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qseA (A:)
sikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvh
minwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgk
cvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhih
rvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpl
sdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >2qseA (A:)
slalsltadqmvsalldaeppilyserpfseasmmglltnladrelvhminwakrvpgfv
dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrncvegmveifdmllat
ssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdtlihlma
kagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahrl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qseB (B:)
sikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvh
minwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgk
cvegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhih
rvldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpl
sdlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >2qseB (B:)
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlih
lmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr
lh

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.