PDB entry 2qe4

View 2qe4 on RCSB PDB site
Description: Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist
Class: transcription
Keywords: nuclear receptor, ligand-binding domain, Alternative splicing, DNA-binding, Lipid-binding, Metal-binding, Nuclear protein, Phosphorylation, Polymorphism, Steroid-binding, Transcription, Transcription regulation, Zinc, Zinc-finger
Deposited on 2007-06-22, released 2007-09-04
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.241
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (77)
      • engineered (113)
    Domains in SCOPe 2.02: d2qe4a_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered (77)
      • engineered (113)
    Domains in SCOPe 2.02: d2qe4b_
  • Heterogens: JJ3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2qe4A (A:)
nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllem
ldahrlha

    Sequence, based on observed residues (ATOM records): (download) 
    >2qe4A (A:)
lalsltadqmvsalldaeppilysepfseasmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2qe4B (B:)
nslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakr
vpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmve
ifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkit
dtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydlllem
ldahrlha

    Sequence, based on observed residues (ATOM records): (download) 
    >2qe4B (B:)
lalsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdq
vhllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrf
rmmnlqgeefvclksiillnsgvytfekdhihrvldkitdtlihlmakagltlqqqhqrl
aqlllilshirhmsnkgmehlysm