PDB entry 2q0b

View 2q0b on RCSB PDB site
Description: Crystal Strucure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic E565A Mutation Responsible for Pfeiffer Syndrome
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, transferase
Deposited on 2007-05-21, released 2007-09-25
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-03-07, with a file datestamp of 2012-03-02.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.202
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (120)
    Domains in SCOPe 2.03: d2q0ba_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (120)
    Domains in SCOPe 2.03: d2q0bb_
  • Heterogens: SO4, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2q0bA (A:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
ayaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee

    Sequence, based on observed residues (ATOM records): (download) 
    >2q0bA (A:)
lpedpkwefprdkltlgkplgqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlv
sememmkmigkhkniinllgactqdgplyvivayaskgnlreylrarrpeeqmtfkdlvs
ctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngrl
pvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkp
anctnelymmmrdcwhavpsqrptfkqlvedldriltltt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2q0bB (B:)
mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
kdkpkeavtvavkmlkddatekdlsdlvsememmkmigkhkniinllgactqdgplyviv
ayaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
sqrptfkqlvedldriltlttnee

    Sequence, based on observed residues (ATOM records): (download) 
    >2q0bB (B:)
lpedpkwefprdkltlgkplgqvvmaeavgidkdkpkeavtvavkmlkddatekdlsdlv
sememmkmigkhkniinllgactqdgplyvivayaskgnlreylrarrppeeqmtfkdlv
sctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngr
lpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdk
panctnelymmmrdcwhavpsqrptfkqlvedldriltlttn