PDB entry 2pzp

View 2pzp on RCSB PDB site
Description: Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K526E Mutation Responsible for Crouzon Syndrome
Class: transferase
Keywords: Kinase Domain Fold Consisting of N- and C-lobes, transferase
Deposited on 2007-05-18, released 2007-09-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-21, with a file datestamp of 2016-12-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (81)
    Domains in SCOPe 2.07: d2pzpa_
  • Chain 'B':
    Compound: Fibroblast growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR2, BEK, KSAM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21802
      • engineered (81)
    Domains in SCOPe 2.07: d2pzpb_
  • Heterogens: SO4, MG, ACP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2pzpA (A:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddateedlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pzpA (A:)
    lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddateedlsdlvs
    ememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrpeeqmtfkdlvsc
    tyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngrlp
    vkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpa
    nctnelymmmrdcwhavpsqrptfkqlvedldriltlttn
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2pzpB (B:)
    mgsshhhhhhsqdpmlagvseyelpedpkwefprdkltlgkplgegafgqvvmaeavgid
    kdkpkeavtvavkmlkddateedlsdlvsememmkmigkhkniinllgactqdgplyviv
    eyaskgnlreylrarrppgmeysydinrvpeeqmtfkdlvsctyqlargmeylasqkcih
    rdlaarnvlvtennvmkiadfglardinnidyykkttngrlpvkwmapealfdrvythqs
    dvwsfgvlmweiftlggspypgipveelfkllkeghrmdkpanctnelymmmrdcwhavp
    sqrptfkqlvedldriltlttnee
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pzpB (B:)
    lpedpkwefprdkltlgkplqvvmaeavgidkdkpkeavtvavkmlkddateedlsdlvs
    ememmkmigkhkniinllgactqdgplyviveyaskgnlreylrarrppgeeqmtfkdlv
    sctyqlargmeylasqkcihrdlaarnvlvtennvmkiadfglardinnidyykkttngr
    lpvkwmapealfdrvythqsdvwsfgvlmweiftlggspypgipveelfkllkeghrmdk
    panctnelymmmrdcwhavpsqrptfkqlvedldriltlttn