PDB entry 2pze

View 2pze on RCSB PDB site
Description: Minimal human CFTR first nucleotide binding domain as a head-to-tail dimer
Class: hydrolase
Keywords: NBD, ABC transporter, CFTR, HYDROLASE
Deposited on 2007-05-17, released 2007-10-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-14, with a file datestamp of 2018-11-09.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (1-18)
      • expression tag (0)
      • variant (52)
    • Uniprot P13569 (19-End)
    Domains in SCOPe 2.08: d2pzea1, d2pzea2
  • Chain 'B':
    Compound: Cystic fibrosis transmembrane conductance regulator
    Species: Homo sapiens [TaxId:9606]
    Gene: CFTR, ABCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13569 (Start-18)
      • variant (52)
    • Uniprot P13569 (19-End)
    Domains in SCOPe 2.08: d2pzeb_
  • Heterogens: MG, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pzeA (A:)
sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
segkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekd
nivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklman
ktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg

    Sequence, based on observed residues (ATOM records): (download) 
    >2pzeA (A:)
sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
segkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekd
nivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklman
ktrilvtskmehlkkadkililhegssyfygtfselqnldfssklm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2pzeB (B:)
sltttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelep
segkikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekd
nivlgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklman
ktrilvtskmehlkkadkililhegssyfygtfselqnlqpdfssklmg

    Sequence, based on observed residues (ATOM records): (download) 
    >2pzeB (B:)
ttevvmenvtafweeggtpvlkdinfkiergqllavagstgagktsllmmimgelepseg
kikhsgrisfcsqfswimpgtikeniifgvsydeyryrsvikacqleediskfaekdniv
lgeggitlsggqrarislaravykdadlylldspfgyldvltekeifescvcklmanktr
ilvtskmehlkkadkililhegssyfygtfselqnlqpd