PDB entry 2pmx

View 2pmx on RCSB PDB site
Description: Human K-Ras in complex with a GTP analogue
Class: structural genomics, unknown function
Keywords: cancer, small gtpase, mutations, gtp analogue, Structural Genomics Consortium, SGC, STRUCTURAL GENOMICS, UNKNOWN FUNCTION
Deposited on 2007-04-23, released 2007-05-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-03-10, with a file datestamp of 2009-03-06.
Experiment type: XRAY
Resolution: 2.27 Å
R-factor: 0.209
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: K-Ras
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2pmxa_
  • Chain 'B':
    Compound: K-Ras
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • cloning artifact (15-17)
    Domains in SCOPe 2.06: d2pmxb1, d2pmxb2
  • Chain 'C':
    Compound: K-Ras
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • cloning artifact (14-17)
    Domains in SCOPe 2.06: d2pmxc1, d2pmxc2
  • Chain 'D':
    Compound: K-Ras
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2pmxd_
  • Chain 'E':
    Compound: K-Ras
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • cloning artifact (15-17)
    Domains in SCOPe 2.06: d2pmxe1, d2pmxe2
  • Chain 'F':
    Compound: K-Ras
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (18-End)
      • cloning artifact (15-17)
    Domains in SCOPe 2.06: d2pmxf1, d2pmxf2
  • Heterogens: MG, GNP, CIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2pmxA (A:)
    mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
    qvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqikr
    vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
    irkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pmxA (A:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
    psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2pmxB (B:)
    mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
    qvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqikr
    vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
    irkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pmxB (B:)
    fqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
    tagsamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlp
    srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2pmxC (C:)
    mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
    qvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqikr
    vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
    irkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pmxC (C:)
    yfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptdsyrkqvvidgetclldildt
    agrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtv
    dtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2pmxD (D:)
    mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
    qvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqikr
    vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
    irkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pmxD (D:)
    mteyklvvvgaggvgksaltiqliqnhfvdedsyrkqvvidgetclldildtagmrtgeg
    flcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsy
    gipfietsaktrqgvddafytlvreirkhk
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >2pmxE (E:)
    mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
    qvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqikr
    vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
    irkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pmxE (E:)
    fqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
    tagrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrt
    vdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >2pmxF (F:)
    mhhhhhhssgrenlyfqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrk
    qvvidgetclldildtagqeeysamrdqymrtgegflcvfainntksfedihhyreqikr
    vkdsedvpmvlvgnkcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvre
    irkhkek
    

    Sequence, based on observed residues (ATOM records): (download)
    >2pmxF (F:)
    fqgmteyklvvvgaggvgksaltiqliqnhfvdedsyrkqvvidgetclldildtadqym
    rtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlpsrtvdtkqaqd
    larsygipfietsaktrqgvddafytlvreirkhk