PDB entry 2pmm

View 2pmm on RCSB PDB site
Description: Crystal structure of active site inhibited coagulation factor VIIA in complex with soluble tissue factor
Class: blood clotting
Keywords: active site inhibitor; substrate profile
Deposited on 2007-04-23, released 2007-05-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2007-05-22, with a file datestamp of 2007-06-01.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.231
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'H':
  Compound: Coagulation factor VII
  Species: HOMO SAPIENS
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-253)
  Domains in SCOPe 2.08: d2pmmh_
• Chain 'I':
  Compound: chloromethyl ketone d-trp-tyr-thr-arg substrate mimicking inhibitor
  
• Chain 'L':
  Compound: Coagulation factor VII
  Species: HOMO SAPIENS
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-93)
  Domains in SCOPe 2.08: d2pmml1, d2pmml2
• Chain 'T':
  Compound: tissue factor
  Species: HOMO SAPIENS
  Gene: ACE
  Database cross-references and differences (RAF-indexed):
  • Uniprot P13726 (0-203)
• Heterogens: GLC, FUC, CA, CH2, HOH

PDB Chain Sequences:

• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2pmmH (H:)
  ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
  lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
  lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
  sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
  seprpgvllrapfp
  

  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2pmmL (L:)
  qcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgt
  krscrchegyslladgvsctptveypcgkipile
  

  
  
• Chain 'T':
  No sequence available.