PDB entry 2pgj

View 2pgj on RCSB PDB site
Description: Catalysis associated conformational changes revealed by human cd38 complexed with a non-hydrolyzable substrate analog
Class: hydrolase
Keywords: Wild-type CD38 bound with N1-cIDPR, the catalytic pocket, conformational changes of the active site, substrate analog binding, HYDROLASE
Deposited on 2007-04-09, released 2007-04-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: 0.192
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • engineered (10)
      • engineered (61)
      • engineered (125)
      • engineered (170)
      • engineered (180)
    Domains in SCOPe 2.08: d2pgja_
  • Chain 'B':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • engineered (10)
      • engineered (61)
      • engineered (125)
      • engineered (170)
      • engineered (180)
    Domains in SCOPe 2.08: d2pgjb_
  • Heterogens: N1C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2pgjA (A:)
kreaearwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhp
cditeedyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdlt
wcgefdtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdk
dstfgsvevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckni
yrpdkflqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >2pgjA (A:)
rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
lqcvknpedssc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2pgjB (B:)
kreaearwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhp
cditeedyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdlt
wcgefdtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdk
dstfgsvevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckni
yrpdkflqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >2pgjB (B:)
rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
vevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
lqcvknpedssc