PDB entry 2pdn
View 2pdn on RCSB PDB site
Description: Human aldose reductase mutant S302R complexed with uracil-type inhibitor.
Class: oxidoreductase
Keywords: TIM barrel, OXIDOREDUCTASE
Deposited on
2007-04-01, released
2008-04-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.17
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: aldose reductase
Species: Homo sapiens [TaxId:9606]
Gene: ALR2
Database cross-references and differences (RAF-indexed):
- Uniprot P15121 (Start-315)
- conflict (4)
- engineered (302)
Domains in SCOPe 2.08: d2pdna_ - Heterogens: NAP, 47D, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2pdnA (A:)
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llrctshkdypfheef
Sequence, based on observed residues (ATOM records): (download)
>2pdnA (A:)
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lrctshkdypfheef