PDB entry 2p55

View 2p55 on RCSB PDB site
Description: X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP
Class: transferase
Keywords: protein kinase structure; Mitogen activated protein kinase kinase; signal transduction; ligand co-complex, ternary co-complex with kinase, ligand and MgATP; non-competitive protein kinase inhibitor, TRANSFERASE
Deposited on 2007-03-14, released 2007-10-02
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.228
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02750 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.03: d2p55a_
  • Heterogens: MG, MRA, ATP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2p55A (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthy
svqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrplssy
gmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhaf
ikrsdaeevdfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >2p55A (A:)
melkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelqvlhe
cnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikgltyl
rekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmavgtrsymsperlqgthysvq
sdiwsmglslvemavgrypipppdakelelmfppmaifelldyivnepppklpsgvfsle
fqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln