PDB entry 2p2q

View 2p2q on RCSB PDB site
Description: Acetyl-CoA Synthetase, R584E mutation
Class: ligase
Keywords: Adenylate-forming enzymes, Domain Alternation, Acyl-CoA ligase, LIGASE
Deposited on 2007-03-07, released 2007-05-29
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: 0.188
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acetyl-coenzyme A synthetase
    Species: Salmonella typhimurium [TaxId:602]
    Gene: acs
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8ZKF6
      • engineered (583)
    Domains in SCOPe 2.01: d2p2qa_
  • Chain 'B':
    Compound: Acetyl-coenzyme A synthetase
    Species: Salmonella typhimurium [TaxId:602]
    Gene: acs
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8ZKF6
      • engineered (583)
    Domains in SCOPe 2.01: d2p2qb_
  • Heterogens: PRX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2p2qA (A:)
msqthkhaipaniadrclinpeqyetkykqsindpdtfwgeqgkildwitpyqkvkntsf
apgnvsikwyedgtlnlaancldrhlqengdrtaiiwegddtsqskhisyrelhrdvcrf
antlldlgikkgdvvaiympmvpeaavamlacarigavhsvifggfspeavagriidsss
rlvitadegvragrsiplkknvddalknpnvtsvehvivlkrtgsdidwqegrdlwwrdl
iekaspehqpeamnaedplfilytsgstgkpkgvlhttggylvyaattfkyvfdyhpgdi
ywctadvgwvtghsyllygplacgattlmfegvpnwptparmcqvvdkhqvnilytapta
iralmaegdkaiegtdrsslrilgsvgepinpeawewywkkigkekcpvvdtwwqtetgg
fmitplpgaielkagsatrpffgvqpalvdneghpqegategnlvitdswpgqartlfgd
herfeqtyfstfknmyfsgdgarrdedgyywitgrvddvlnvsghrlgtaeiesalvahp
kiaeaavvgiphaikgqaiyayvtlnhgeepspelyaevrnwvekeigplatpdvlhwtd
slpktrsgkimrrilrkiaagdtsnlgdtstladpgvveklleekqaiamps

    Sequence, based on observed residues (ATOM records): (download) 
    >2p2qA (A:)
khaipaniadrclinpeqyetkykqsindpdtfwgeqgkildwitpyqkvkntsfapgnv
sikwyedgtlnlaancldrhlqengdrtaiiwegddtsqskhisyrelhrdvcrfantll
dlgikkgdvvaiympmvpeaavamlacarigavhsvifggfspeavagriidsssrlvit
adegvragrsiplkknvddalknpnvtsvehvivlkrtgsdidwqegrdlwwrdliekas
pehqpeamnaedplfilytsgstgkpkgvlhttggylvyaattfkyvfdyhpgdiywcta
dvgwvtghsyllygplacgattlmfegvpnwptparmcqvvdkhqvnilytaptairalm
aegdkaiegtdrsslrilgsvgepinpeawewywkkigkekcpvvdtwwqtetggfmitp
lpgaielkagsatrpffgvqpalvdneghpqegategnlvitdswpgqartlfgdherfe
qtyfstfknmyfsgdgarrdedgyywitgrvddvlnvsghrlgtaeiesalvahpkiaea
avvgiphaikgqaiyayvtlnhgeepspelyaevrnwvekeigplatpdvlhwtdslpkt
rsgkimrrilrkiaagdtsadpgvveklleekqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2p2qB (B:)
msqthkhaipaniadrclinpeqyetkykqsindpdtfwgeqgkildwitpyqkvkntsf
apgnvsikwyedgtlnlaancldrhlqengdrtaiiwegddtsqskhisyrelhrdvcrf
antlldlgikkgdvvaiympmvpeaavamlacarigavhsvifggfspeavagriidsss
rlvitadegvragrsiplkknvddalknpnvtsvehvivlkrtgsdidwqegrdlwwrdl
iekaspehqpeamnaedplfilytsgstgkpkgvlhttggylvyaattfkyvfdyhpgdi
ywctadvgwvtghsyllygplacgattlmfegvpnwptparmcqvvdkhqvnilytapta
iralmaegdkaiegtdrsslrilgsvgepinpeawewywkkigkekcpvvdtwwqtetgg
fmitplpgaielkagsatrpffgvqpalvdneghpqegategnlvitdswpgqartlfgd
herfeqtyfstfknmyfsgdgarrdedgyywitgrvddvlnvsghrlgtaeiesalvahp
kiaeaavvgiphaikgqaiyayvtlnhgeepspelyaevrnwvekeigplatpdvlhwtd
slpktrsgkimrrilrkiaagdtsnlgdtstladpgvveklleekqaiamps

    Sequence, based on observed residues (ATOM records): (download) 
    >2p2qB (B:)
hkhaipaniadrclinpeqyetkykqsindpdtfwgeqgkildwitpyqkvkntsfapgn
vsikwyedgtlnlaancldrhlqengdrtaiiwegddtsqskhisyrelhrdvcrfantl
ldlgikkgdvvaiympmvpeaavamlacarigavhsvifggfspeavagriidsssrlvi
tadegvragrsiplkknvddalknpnvtsvehvivlkrtgsdidwqegrdlwwrdlieka
spehqpeamnaedplfilytsgstgkpkgvlhttggylvyaattfkyvfdyhpgdiywct
advgwvtghsyllygplacgattlmfegvpnwptparmcqvvdkhqvnilytaptairal
maegdkaiegtdrsslrilgsvgepinpeawewywkkigkekcpvvdtwwqtetggfmit
plpgaielkagsatrpffgvqpalvdneghpqegategnlvitdswpgqartlfgdherf
eqtyfstfknmyfsgdgarrdedgyywitgrvddvlnvsghrlgtaeiesalvahpkiae
aavvgiphaikgqaiyayvtlnhgeepspelyaevrnwvekeigplatpdvlhwtdslpk
trsgkimrrilrkiaagdtladpgvveklleekqai