PDB entry 2p2i

View 2p2i on RCSB PDB site
Description: Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor
Class: Transferase
Keywords: receptor tyrosine kinase, KDR, Transferase
Deposited on 2007-03-07, released 2007-03-20
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.222
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968 (Start-124)
      • engineered (2)
      • engineered (125)
      • cloning artifact (307)
      • expression tag (308-313)
    • Uniprot P35968 (125-306)
    Domains in SCOPe 2.03: d2p2ia_
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2p2ib_
  • Heterogens: 608, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2p2iA (A:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2p2iA (A:)
aerlpydaskwefprdrlklgkplgrgafgqvieadafgidtcrtvavkmlthsehralm
selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykvape
dlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglalpl
kwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapd
yttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqdrhhhhhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2p2iB (B:)
ehaerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkega
thsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrne
fvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvki
cdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgas
pypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnll
qanaqqdrhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2p2iB (B:)
lpydaskwefprdrlklgkplgrgqvieadafgidktatcrtvavkmlthsehralmsel
kilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykfltlehl
icysfqvakgmeflasrkcihrdlaarnillseknvvkicdfplkwmapetifdrvytiq
sdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhg
epsqrptfselvehlgnllqana