PDB entry 2ow1

View 2ow1 on RCSB PDB site
Description: MMP-9 active site mutant with trifluoromethyl hydroxamate inhibitor
Class: Hydrolase
Keywords: matrix metalloproteinase, hydrolase, s1-prime pocket
Deposited on 2007-02-15, released 2007-06-19
The last revision prior to the SCOP 1.75 freeze date was dated 2007-08-14, with a file datestamp of 2007-08-10.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.217
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Matrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB)
    Species: HOMO SAPIENS
    Gene: MMP9, CLG4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14780 (0-105)
      • engineered (117)
    • Uniprot P14780 (106-158)
    Domains in SCOP 1.75: d2ow1a1
  • Chain 'B':
    Compound: Matrix metalloproteinase-9 (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB)
    Species: HOMO SAPIENS
    Gene: MMP9, CLG4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14780 (Start-105)
      • engineered (117)
    • Uniprot P14780 (106-158)
    Domains in SCOP 1.75: d2ow1b1
  • Heterogens: ZN, CA, CL, 7MR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2ow1A (A:)
fegdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviq
fgvaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfg
halgldhssvpealmypmyrftegpplhkddvngirhly

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2ow1B (B:)
fegdlkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviq
fgvaehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfg
halgldhssvpealmypmyrftegpplhkddvngirhly

    Sequence, based on observed residues (ATOM records): (download) 
    >2ow1B (B:)
lkwhhhnitywiqnysedlpraviddafarafalwsavtpltftrvysrdadiviqfgva
ehgdgypfdgkdgllahafppgpgiqgdahfdddelwslgkgqgyslflvaahqfghalg
ldhssvpealmypmyrftegpplhkddvngirhly