PDB entry 2ops

View 2ops on RCSB PDB site
Description: Crystal Structure of Y188C Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, nnrti, gw420867x, drug resistance, transferase
Deposited on 2007-01-30, released 2007-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.218
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1 [TaxId:11706]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-541)
      • engineered (186)
      • modified residue (278)
    Domains in SCOPe 2.08: d2opsa2, d2opsa3
  • Chain 'B':
    Compound: p51 RT
    Species: Human immunodeficiency virus 1 [TaxId:11706]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-434)
      • engineered (182)
    Domains in SCOPe 2.08: d2opsb_
  • Heterogens: PO4, HBQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2opsA (A:)
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpld
edfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviy
qymddlcvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtv
qpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeael
elaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgah
tndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpp
lvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqa
iylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkg
ig

    Sequence, based on observed residues (ATOM records): (download) 
    >2opsA (A:)
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrky
taftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddl
cvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlp
ekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenr
eilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkq
lteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwy
qlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiylalq
dsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgig

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2opsB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlcvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >2opsB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfiphpaglkkkksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlcvgs
dleigqhrtkieelrqhllrwelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiy
pgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqk
qgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfkl
piqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetf