PDB entry 2opr

View 2opr on RCSB PDB site
Description: Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, nnrti, gw420867x, drug resistance, transferase
Deposited on 2007-01-30, released 2007-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.232
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1 [TaxId:11706]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-546)
      • engineered (99)
      • modified residue (278)
    Domains in SCOPe 2.08: d2opra1, d2opra2
  • Chain 'B':
    Compound: p51 RT
    Species: Human immunodeficiency virus 1 [TaxId:11706]
    Gene: gag-pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-425)
      • engineered (95)
    Domains in SCOPe 2.08: d2oprb_
  • Heterogens: HBQ

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2oprA (A:)
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvf
aikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglekkksvtvldvgdayfsvpld
edfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviy
qymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtv
qpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeael
elaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgah
tndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpp
lvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqa
iylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkg
iggneqv

    Sequence, based on observed residues (ATOM records): (download) 
    >2oprA (A:)
ispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskignpyntpvfai
kwrklvdfrelnkrtqdfwevqlgiphpaglekkksvtvldvgdayfsvpldedfrkyta
ftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyv
gsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpek
dswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenrei
lkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlt
eavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql
ekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiylalqds
glevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneqv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2oprB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfwevqlgiphpaglekkksvtvldvgdayfsvpldedfr
kytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymd
dlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpiv
lpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelae
nreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndv
kqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvkl
wyqlek

    Sequence, based on observed residues (ATOM records): (download) 
    >2oprB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfiphpaglekkksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiy
pgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqk
qgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfkl
piqketwetwwteywqatwipewefvntpplvklwyqlek