PDB entry 2onc

View 2onc on RCSB PDB site
Description: Crystal structure of human DPP-4
Class: hydrolase
Keywords: DPP4 protein-inhibitor complex, HYDROLASE
Deposited on 2007-01-23, released 2008-03-04
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.198
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (5-730)
      • expression tag (4)
    Domains in SCOPe 2.05: d2onca1, d2onca2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (5-730)
      • expression tag (0-4)
    Domains in SCOPe 2.05: d2oncb1, d2oncb2
  • Chain 'C':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (5-730)
      • expression tag (4)
    Domains in SCOPe 2.05: d2oncc1, d2oncc2
  • Chain 'D':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27487 (5-730)
      • expression tag (4)
    Domains in SCOPe 2.05: d2oncd1, d2oncd2
  • Heterogens: NAG, SY1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2oncA (A:)
hhasaktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstf
defghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwv
twspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalw
wspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntds
lssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessg
rwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdct
fitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercq
yysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkld
fiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiv
asfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyv
tsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenf
kqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythm
shfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >2oncA (A:)
aktytltdylkntyrlklyslrwisdheylyknilvfnaeygnssvflenstfdefghsi
ndysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvgh
klayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtf
layaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtna
tsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclva
rqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfitkgtw
evigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfs
keakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnet
kfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrg
sgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgs
gsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyll
ihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqc
fslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2oncB (B:)
hhasaktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstf
defghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwv
twspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalw
wspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntds
lssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessg
rwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdct
fitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercq
yysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkld
fiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiv
asfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyv
tsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenf
kqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythm
shfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >2oncB (B:)
hhasaktytltdylkntyrlklyslrwisdheylyknilvfnaeygnssvflenstfdef
ghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtws
pvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwsp
ngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslss
vtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwn
clvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfit
kgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyys
vsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfii
lnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasf
dgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsm
vlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqv
eyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshf
ikqcfslp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2oncC (C:)
hhasaktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstf
defghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwv
twspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalw
wspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntds
lssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessg
rwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdct
fitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercq
yysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkld
fiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiv
asfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyv
tsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenf
kqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythm
shfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >2oncC (C:)
aktytltdylkntyrlklyslrwisdheylyknnilvfnaeygnssvflenstfdefghs
indysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvg
hklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngt
flayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtn
atsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclv
arqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkctfitkgtwe
vigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfsk
eakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnetk
fwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrgs
gyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgsg
sgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveylli
hgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqcf
slp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2oncD (D:)
hhasaktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstf
defghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwv
twspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalw
wspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntds
lssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessg
rwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdct
fitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercq
yysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkld
fiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniiv
asfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyv
tsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenf
kqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythm
shfikqcfslp

    Sequence, based on observed residues (ATOM records): (download) 
    >2oncD (D:)
aktytltdylkntyrlklyslrwisdheylyknilvfnaeygnssvflenstfdefghsi
ndysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtwspvgh
klayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwwspngtf
layaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdslssvtna
tsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrwnclva
rqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqiddctfitkgtwev
igiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyysvsfske
akyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfiilnetkf
wyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivasfdgrgsg
yqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvtsmvlgsgs
gvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkqveyllih
gtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmshfikqcfs
lp