PDB entry 2oh4

View 2oh4 on RCSB PDB site
Description: Crystal structure of Vegfr2 with a benzimidazole-urea inhibitor
Class: Transferase
Keywords: Vascular endothelial growth factor receptor 2 Tyrosine-protein kinase 3D-structure VEGFR2 Angiogenesis ATP-binding Phosphorylation EC 2.7.1.112 VEGFR-2 Kinase insert domain receptor Protein-tyrosine kinase receptor Flk-1, Transferase
Deposited on 2007-01-09, released 2007-09-18
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.189
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35968
      • expression tag (11)
      • conflict (30)
      • modified residue (198)
      • modified residue (203)
    • Uniprot P35968 (Start-315)
    Domains in SCOPe 2.02: d2oh4a_
  • Heterogens: SO4, GIG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2oh4A (A:)
hmdpdelpldehcerlpydaskwefprdrlnlgkplgrgafgqvieadafgidktatcrt
vavkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnl
stylrskrnefvpyktpedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnil
lseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvll
weifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfse
lvehlgnllqanaqqd

    Sequence, based on observed residues (ATOM records): (download) 
    >2oh4A (A:)
hcerlpydaskwefprdrlnlgkplgrgafgqvieadafgidktatcrtvavkmlkegat
hsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnef
vpyykdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglard
iykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvllweifslgaspypgvkid
eefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfselvehlgnllqanaqqd