PDB entry 2ocf

View 2ocf on RCSB PDB site
Description: Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody
Class: hormone/growth factor
Keywords: Estrogen Receptor, LBD, monobody, estradiol, HORMONE-GROWTH FACTOR COMPLEX
Deposited on 2006-12-20, released 2007-11-06
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-08-03, with a file datestamp of 2011-07-29.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.194
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • modified residue (83)
      • modified residue (119)
      • engineered (239)
    Domains in SCOPe 2.04: d2ocfa_
  • Chain 'D':
    Compound: Fibronectin
    Species: Homo sapiens [TaxId:9606]
    Gene: CIG, FN1, FN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02751 (Start-120)
      • engineered (32-33)
      • engineered (104-108)
      • engineered (110)
    Domains in SCOPe 2.04: d2ocfd_
  • Heterogens: EST, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ocfA (A:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhaptsrggasveetdqshlatagstsshslqkyyitgeaegfpatv

    Sequence, based on observed residues (ATOM records): (download) 
    >2ocfA (A:)
slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
fdmllatssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagl
tlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplsdlllemldahr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2ocfD (D:)
mkhhhhhhssdykddddkgenlyfqgsvsdvptklevvaatptslliswdapavtvryyr
itygetggnspvqeftvpgskstatisglkpgvdytitvyavtglrlmlagskpisinyr
t

    Sequence, based on observed residues (ATOM records): (download) 
    >2ocfD (D:)
sdvptklevvaatptslliswdapavtvryyritygetggnspvqeftvpgskstatisg
lkpgvdytitvyavtglrlmlagskpisinyrt