PDB entry 2o8y

View 2o8y on RCSB PDB site
Description: Apo IRAK4 Kinase Domain
Class: Transferase
Keywords: Protein kinase, immunodeficiency, inflammation, Transferase
Deposited on 2006-12-12, released 2007-12-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.244
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (29)
      • modified residue (74)
      • modified residue (102)
      • modified residue (124)
      • modified residue (179)
      • modified residue (181-182)
      • modified residue (192)
      • modified residue (255)
      • modified residue (266)
      • modified residue (294)
    Domains in SCOPe 2.06: d2o8ya_
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NWZ3
      • modified residue (29)
      • modified residue (74)
      • modified residue (102)
      • modified residue (124)
      • modified residue (179)
      • modified residue (181-182)
      • modified residue (192)
      • modified residue (255)
      • modified residue (266)
      • modified residue (294)
    Domains in SCOPe 2.06: d2o8yb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2o8yA (A:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2o8yA (A:)
fhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkllkqqfdqei
kvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmrckiaqg
aanginflhenhhihrdiksanilldeaftakisdfglarastvmtsrivgttaymapea
lrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektiedyidkkmn
dadstsveamysvasqclhekknkrpdikkvqqllqemta

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2o8yB (B:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemtas

    Sequence, based on observed residues (ATOM records): (download) 
    >2o8yB (B:)
fhsfsfyelknvtnnfderpignkmgeggfgvvykgyvnnttvavkklkqqfdqeikvma
kcqhenlvellgfssdgddlclvyvympngslldrlscldgtpplswhmrckiaqgaang
inflhenhhihrdiksanilldeaftakisdfglarasqtvmtsrivgttaymapealrg
eitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeektiedyidkkmndad
stsveamysvasqclhekknkrpdikkvqqllqemta