PDB entry 2o3u

View 2o3u on RCSB PDB site
Description: Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38
Class: hydrolase
Keywords: Human CD38 E226Q mutant, the catalytic pocket, NGD binding and hydrolysis, HYDROLASE
Deposited on 2006-12-01, released 2006-12-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.18
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • engineered (10)
      • engineered (61)
      • engineered (125)
      • engineered (170)
      • engineered (180)
      • engineered (187)
    Domains in SCOPe 2.06: d2o3ua_
  • Chain 'B':
    Compound: ADP-ribosyl cyclase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (6-End)
      • engineered (10)
      • engineered (61)
      • engineered (125)
      • engineered (170)
      • engineered (180)
      • engineered (187)
    Domains in SCOPe 2.06: d2o3ub_
  • Heterogens: NGD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2o3uA (A:)
    kreaearwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhp
    cditeedyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdlt
    wcgefdtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdk
    dstfgsvqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckni
    yrpdkflqcvknpedssctsei
    

    Sequence, based on observed residues (ATOM records): (download)
    >2o3uA (A:)
    rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
    dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
    tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
    vqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
    lqcvknpedssc
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2o3uB (B:)
    kreaearwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhp
    cditeedyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdlt
    wcgefdtskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdk
    dstfgsvqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckni
    yrpdkflqcvknpedssctsei
    

    Sequence, based on observed residues (ATOM records): (download)
    >2o3uB (B:)
    rwrqtwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcditee
    dyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgefd
    tskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfgs
    vqvhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdkf
    lqcvknpedssc