PDB entry 2nt1

View 2nt1 on RCSB PDB site
Description: Structure of acid-beta-glucosidase at neutral pH
Class: Hydrolase
Keywords: acid-beta-glucosidase, cerezyme, glucosylceramide, gaucher disease
Deposited on 2006-11-06, released 2006-12-26
The last revision prior to the SCOP 1.73 freeze date was dated 2007-01-30, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.178
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: HOMO SAPIENS
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOP 1.73: d2nt1a1, d2nt1a2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: HOMO SAPIENS
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOP 1.73: d2nt1b1, d2nt1b2
  • Chain 'C':
    Compound: glucosylceramidase
    Species: HOMO SAPIENS
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOP 1.73: d2nt1c1, d2nt1c2
  • Chain 'D':
    Compound: glucosylceramidase
    Species: HOMO SAPIENS
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOP 1.73: d2nt1d1, d2nt1d2
  • Heterogens: NAG, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nt1A (A:)
    arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
    tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
    vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
    sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
    lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
    aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
    mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
    ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
    etispgysihtylwhrq
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nt1B (B:)
    arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
    tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
    vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
    sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
    lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
    aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
    mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
    ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
    etispgysihtylwhrq
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nt1C (C:)
    arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
    tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
    vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
    sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
    lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
    aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
    mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
    ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
    etispgysihtylwhrq
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2nt1D (D:)
    arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
    tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
    vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
    sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
    lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
    aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
    mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
    ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
    etispgysihtylwhrq