PDB entry 2nsx

View 2nsx on RCSB PDB site
Description: Structure of acid-beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease
Class: Hydrolase
Keywords: TIM-barrel glycosidase Cerezyme hydrolysis, Hydrolase
Deposited on 2006-11-06, released 2006-12-26
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.11 Å
R-factor: 0.193
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOPe 2.01: d2nsxa1, d2nsxa2
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOPe 2.01: d2nsxb1, d2nsxb2
  • Chain 'C':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOPe 2.01: d2nsxc1, d2nsxc2
  • Chain 'D':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Gene: GBA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04062 (0-496)
      • conflict (494)
    Domains in SCOPe 2.01: d2nsxd1, d2nsxd2
  • Heterogens: NAG, NDG, SO4, IFM, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nsxA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nsxB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nsxC (C:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2nsxD (D:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq