PDB entry 2np0

View 2np0 on RCSB PDB site
Description: Crystal structure of the Botulinum neurotoxin type B complexed with synaptotagamin-II ectodomain
Class: hydrolase
Keywords: botulinum, neurotoxin, synaptotagamin, receptor, hydrolase
Deposited on 2006-10-26, released 2006-12-26
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: 0.188
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: botulinum neurotoxin type b
    Species: Clostridium botulinum [TaxId:1491]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d2np0a1, d2np0a2, d2np0a3, d2np0a4
  • Chain 'B':
    Compound: Synaptotagmin-2
    Species: Mus musculus [TaxId:10090]
    Gene: Syt2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, CA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2np0A (A:)
pvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfnk
ssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylgd
rrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnhf
asregfggimqmkfcpeyvsvfnnvqenkgasifnrrgyfsdpalilmhelihvlhglyg
ikvddlpivpnekkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgivd
rlnkvlvcisdpnininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetni
aenykiktrasyfsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqay
eeiskehlavykiqmcksvkapgicidvdnedlffiadknsfsddlsknerieyntqsny
iendfpinelildtdliskielpsentesltdfnvdvpvyekqpaikkiftdentifqyl
ysqtfpldirdisltssfddallfsnkvysffsmdyiktankvveaglfagwvkqivndf
vieanksntmdkiadislivpyiglalnvgnetakgnfenafeiagasillefipellip
vvgafllesyidnknkiiktidnaltkrnekwsdmyglivaqwlstvntqfytikegmyk
alnyqaqaleeiikyryniysekeksninidfndinsklneginqaidninnfingcsvs
ylmkkmiplaveklldfdntlkknllnyidenklyligsaeyekskvnkylktimpfdls
iytndtiliemfnkynseilnniilnlrykdnnlidlsgygakvevydgvelndknqfkl
tssanskirvtqnqniifnsvfldfsvsfwiripkykndgiqnyihneytiincmknnsg
wkisirgnriiwtlidingktksvffeynirediseyinrwffvtitnnlnnakiyingk
lesntdikdireviangeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsys
eylkdfwgnplmynkeyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdlyi
gekfiirrksnsqsinddivrkedyiyldffnlnqewrvytykyfkkeeeklflapisds
defyntiqikeydeqptyscqllfkkdeestdeigligihrfyesgivfeeykdyfcisk
wylkevkrkpynlklgcnwqfipkdegwte

    Sequence, based on observed residues (ATOM records): (download) 
    >2np0A (A:)
pvtinnfnyndpidnnniimmeppfargtgryykafkitdriwiiperytfgykpedfnk
ssgifnrdvceyydpdylntndkkniflqtmiklfnrikskplgekllemiingipylgd
rrvpleefntniasvtvnklisnpgeverkkgifanliifgpgpvlnenetidigiqnhf
asregfggimqmkfcpeyvsvfnnvqenkgasifnrrgyfsdpalilmhelihvlhglyg
ikvddlpivpnekkffmqstdaiqaeelytfggqdpsiitpstdksiydkvlqnfrgivd
rlnkvlvcisdpnininiyknkfkdkykfvedsegkysidvesfdklykslmfgftetni
aenykiktrasyfsdslppvkiknlldneiytieegfnisdkdmekeyrgqnkainkqay
eeiskehlavykiqmcksvkpgicidvdnedlffiadknsfsddlsknerieyntqsnyi
endfpinelildtdliskielpsentesltdfnvdvpvyekqpaikkiftdentifqyly
sqtfpldirdisltssfddallfsnkvysffsmdyiktankvveaglfagwvkqivndfv
ieanksntmdkiadislivpyiglalnvgnetakgnfenafeiagasillefipellipv
vgafllesyidnknkiiktidnaltkrnekwsdmyglivaqwlstvntqfytikegmyka
lnyqaqaleeiikyryniysekeksninidfndinsklneginqaidninnfingcsvsy
lmkkmiplaveklldfdntlkknllnyidenklyligsaeyekskvnkylktimpfdlsi
ytndtiliemfnkynseilnniilnlrykdnnlidlsgygakvevydgvelndknqfklt
ssanskirvtqnqniifnsvfldfsvsfwiripkykndgiqnyihneytiincmknnsgw
kisirgnriiwtlidingktksvffeynirediseyinrwffvtitnnlnnakiyingkl
esntdikdireviangeiifkldgdidrtqfiwmkyfsifntelsqsnieerykiqsyse
ylkdfwgnplmynkeyymfnagnknsyiklkkdspvgeiltrskynqnskyinyrdlyig
ekfiirrksnsqsinddivrkedyiyldffnlnqewrvytykyfkkeeeklflapisdsd
efyntiqikeydeqptyscqllfkkdeestdeigligihrfyesgivfeeykdyfciskw
ylkevkrkpynlklgcnwqfipkdegwte

  • Chain 'B':
    No sequence available.