PDB entry 2jlx

View 2jlx on RCSB PDB site
Description: dengue virus 4 ns3 helicase in complex with ssrna and ADP-vanadate
Class: hydrolase/RNA
Keywords: hydrolase-RNA complex, hydrolase RNA complex, envelope protein, ribonucleoprotein, capsid protein, RNA replication, serine protease, glycoprotein, dengue virus, metal-binding, transferase, ATP-binding, RNA-binding, flaviviruses, transcription regulation, RNA-directed RNA polymerase, nucleotide-binding, viral nucleoprotein, secreted, helicase, vanadate, protease, hydrolase, cleavage on pair of basic residues, endoplasmic reticulum, nucleotidyltransferase, ADP, ssrna, virion, ATPase, nucleus, membrane, transmembrane, transcription, phosphoprotein, ns3 helicase structure, multifunctional enzyme
Deposited on 2008-09-15, released 2008-11-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.19819
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine protease subunit ns3
    Species: DENGUE VIRUS 4 [TaxId:408688]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JLX (0-3)
      • conflict (82)
      • conflict (124)
      • conflict (153-154)
      • conflict (213)
      • conflict (312)
    • Uniprot Q2YHF0 (4-450)
    Domains in SCOPe 2.06: d2jlxa1, d2jlxa2, d2jlxa3
  • Chain 'B':
    Compound: serine protease subunit ns3
    Species: DENGUE VIRUS 4 [TaxId:408688]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JLX (0-3)
      • conflict (82)
      • conflict (124)
      • conflict (153-154)
      • conflict (213)
      • conflict (312)
    • Uniprot Q2YHF0 (4-450)
    Domains in SCOPe 2.06: d2jlxb1, d2jlxb2
  • Chain 'C':
    Compound: 5'-r(*ap*gp*ap*cp*up*ap*ap*cp*ap*ap*cp*u)-3'
  • Chain 'D':
    Compound: 5'-r(*ap*gp*ap*cp*up*ap*ap*cp*ap*ap*cp*u)-3'
  • Heterogens: ADP, VO4, MN, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2jlxA (A:)
gsamgepdyevdedifrkkrltimdlhpgagktkrilpsivrealkrrlrtlilaptrvv
aaemeealrglpiryqtpavksdhtgreivdlmchatfttrllsstrvpnynlivmdeah
ftdpcsvaargyistrvemgeaaaifmtatppgsidpfpqsnspiediereiperswntg
fdwitdyqgktvwfvpsikagndianclrksgkrviqlsrktfdteypktkltdwdfvvt
tdisemganfragrvidprrclkpviltdgpervilagpipvtpasaaqrrgrigrnpaq
eddqyvfsgdplkndedhahwteakmlldniytpegiiptlfgperektqaidgefrlrg
eqrktfvelmrrgdlpvwlsykvasagisykdrewcftgernnqileenmeveiwtrege
kkklrpkwldarvyadpmalkdfkefasgrk

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2jlxB (B:)
gsamgepdyevdedifrkkrltimdlhpgagktkrilpsivrealkrrlrtlilaptrvv
aaemeealrglpiryqtpavksdhtgreivdlmchatfttrllsstrvpnynlivmdeah
ftdpcsvaargyistrvemgeaaaifmtatppgsidpfpqsnspiediereiperswntg
fdwitdyqgktvwfvpsikagndianclrksgkrviqlsrktfdteypktkltdwdfvvt
tdisemganfragrvidprrclkpviltdgpervilagpipvtpasaaqrrgrigrnpaq
eddqyvfsgdplkndedhahwteakmlldniytpegiiptlfgperektqaidgefrlrg
eqrktfvelmrrgdlpvwlsykvasagisykdrewcftgernnqileenmeveiwtrege
kkklrpkwldarvyadpmalkdfkefasgrk

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.