PDB entry 2jkv

View 2jkv on RCSB PDB site
Description: structure of human phosphogluconate dehydrogenase in complex with nadph at 2.53a
Class: oxidoreductase
Keywords: oxidoreductase, phosphogluconate, nadp, nadph, pentose shunt, dehydrogenase
Deposited on 2008-09-01, released 2009-09-01
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-09-01, with a file datestamp of 2009-08-28.
Experiment type: XRAY
Resolution: 2.53 Å
R-factor: 0.1566
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 6-phosphogluconate dehydrogenase, decarboxylating
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JKV
    • Uniprot P52209 (Start-504)
    Domains in SCOPe 2.05: d2jkva1, d2jkva2
  • Chain 'B':
    Compound: 6-phosphogluconate dehydrogenase, decarboxylating
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JKV
    • Uniprot P52209 (Start-504)
    Domains in SCOPe 2.05: d2jkvb1, d2jkvb2
  • Chain 'C':
    Compound: 6-phosphogluconate dehydrogenase, decarboxylating
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JKV
    • Uniprot P52209 (Start-504)
    Domains in SCOPe 2.05: d2jkvc1, d2jkvc2
  • Chain 'D':
    Compound: 6-phosphogluconate dehydrogenase, decarboxylating
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JKV
    • Uniprot P52209 (Start-504)
    Domains in SCOPe 2.05: d2jkvd1, d2jkvd2
  • Chain 'E':
    Compound: 6-phosphogluconate dehydrogenase, decarboxylating
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2JKV
    • Uniprot P52209 (Start-504)
    Domains in SCOPe 2.05: d2jkve1, d2jkve2
  • Chain 'F':
    Compound: 6-phosphogluconate dehydrogenase, decarboxylating
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2jkvf1, d2jkvf2
  • Heterogens: NAP, CL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2jkvA (A:)
mhhhhhhssgvdlgtenlyfqsmaqadialiglavmgqnlilnmndhgfvvcafnrtvsk
vddflaneakgtkvvgaqslkemvsklkkprriillvkagqavddfieklvplldtgdii
idggnseyrdttrrcrdlkakgilfvgsgvsggeegarygpslmpggnkeawphiktifq
giaakvgtgepccdwvgdegaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaq
afedwnkteldsflieitanilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpv
tligeavfarclsslkderiqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqg
fmllrqaatefgwtlnyggialmwrggciirsvflgkikdafdrnpelqnlllddffksa
vencqdswrravstgvqagipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyell
akpgqfihtnwtghggtvssssyna

    Sequence, based on observed residues (ATOM records): (download) 
    >2jkvA (A:)
aqadialiglavmgqnlilnmndhgfvvcafnrtvskvddflaneakgtkvvgaqslkem
vsklkkprriillvkagqavddfieklvplldtgdiiidggnseyrdttrrcrdlkakgi
lfvgsgvsggeegarygpslmpggnkeawphiktifqgiaakvgtgepccdwvgdegagh
fvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieitanilk
fqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkderiqas
kklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggialm
wrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagipmp
cfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwtghggtvssssy
na

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2jkvB (B:)
mhhhhhhssgvdlgtenlyfqsmaqadialiglavmgqnlilnmndhgfvvcafnrtvsk
vddflaneakgtkvvgaqslkemvsklkkprriillvkagqavddfieklvplldtgdii
idggnseyrdttrrcrdlkakgilfvgsgvsggeegarygpslmpggnkeawphiktifq
giaakvgtgepccdwvgdegaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaq
afedwnkteldsflieitanilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpv
tligeavfarclsslkderiqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqg
fmllrqaatefgwtlnyggialmwrggciirsvflgkikdafdrnpelqnlllddffksa
vencqdswrravstgvqagipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyell
akpgqfihtnwtghggtvssssyna

    Sequence, based on observed residues (ATOM records): (download) 
    >2jkvB (B:)
aqadialiglavmgqnlilnmndhgfvvcafnrtvskvddflaneakgtkvvgaqslkem
vsklkkprriillvkagqavddfieklvplldtgdiiidggnseyrdttrrcrdlkakgi
lfvgsgvsggeegarygpslmpggnkeawphiktifqgiaakvgtgepccdwvgdegagh
fvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieitanilk
fqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkderiqas
kklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggialm
wrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagipmp
cfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwtghggtvssssy
na

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2jkvC (C:)
mhhhhhhssgvdlgtenlyfqsmaqadialiglavmgqnlilnmndhgfvvcafnrtvsk
vddflaneakgtkvvgaqslkemvsklkkprriillvkagqavddfieklvplldtgdii
idggnseyrdttrrcrdlkakgilfvgsgvsggeegarygpslmpggnkeawphiktifq
giaakvgtgepccdwvgdegaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaq
afedwnkteldsflieitanilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpv
tligeavfarclsslkderiqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqg
fmllrqaatefgwtlnyggialmwrggciirsvflgkikdafdrnpelqnlllddffksa
vencqdswrravstgvqagipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyell
akpgqfihtnwtghggtvssssyna

    Sequence, based on observed residues (ATOM records): (download) 
    >2jkvC (C:)
aqadialiglavmgqnlilnmndhgfvvcafnrtvskvddflaneakgtkvvgaqslkem
vsklkkprriillvkagqavddfieklvplldtgdiiidggnseyrdttrrcrdlkakgi
lfvgsgvsggeegarygpslmpggnkeawphiktifqgiaakvgtgepccdwvgdegagh
fvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieitanilk
fqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkderiqas
kklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggialm
wrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagipmp
cfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwtghggtvssssy
na

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2jkvD (D:)
mhhhhhhssgvdlgtenlyfqsmaqadialiglavmgqnlilnmndhgfvvcafnrtvsk
vddflaneakgtkvvgaqslkemvsklkkprriillvkagqavddfieklvplldtgdii
idggnseyrdttrrcrdlkakgilfvgsgvsggeegarygpslmpggnkeawphiktifq
giaakvgtgepccdwvgdegaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaq
afedwnkteldsflieitanilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpv
tligeavfarclsslkderiqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqg
fmllrqaatefgwtlnyggialmwrggciirsvflgkikdafdrnpelqnlllddffksa
vencqdswrravstgvqagipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyell
akpgqfihtnwtghggtvssssyna

    Sequence, based on observed residues (ATOM records): (download) 
    >2jkvD (D:)
aqadialiglavmgqnlilnmndhgfvvcafnrtvskvddflaneakgtkvvgaqslkem
vsklkkprriillvkagqavddfieklvplldtgdiiidggnseyrdttrrcrdlkakgi
lfvgsgvsggeegarygpslmpggnkeawphiktifqgiaakvgtgepccdwvgdegagh
fvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieitanilk
fqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkderiqas
kklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggialm
wrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagipmp
cfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwtghggtvssssy
na

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2jkvE (E:)
mhhhhhhssgvdlgtenlyfqsmaqadialiglavmgqnlilnmndhgfvvcafnrtvsk
vddflaneakgtkvvgaqslkemvsklkkprriillvkagqavddfieklvplldtgdii
idggnseyrdttrrcrdlkakgilfvgsgvsggeegarygpslmpggnkeawphiktifq
giaakvgtgepccdwvgdegaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaq
afedwnkteldsflieitanilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpv
tligeavfarclsslkderiqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqg
fmllrqaatefgwtlnyggialmwrggciirsvflgkikdafdrnpelqnlllddffksa
vencqdswrravstgvqagipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyell
akpgqfihtnwtghggtvssssyna

    Sequence, based on observed residues (ATOM records): (download) 
    >2jkvE (E:)
aqadialiglavmgqnlilnmndhgfvvcafnrtvskvddflaneakgtkvvgaqslkem
vsklkkprriillvkagqavddfieklvplldtgdiiidggnseyrdttrrcrdlkakgi
lfvgsgvsggeegarygpslmpggnkeawphiktifqgiaakvgtgepccdwvgdegagh
fvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieitanilk
fqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkderiqas
kklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggialm
wrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagipmp
cfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwtghggtvssssy
na

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2jkvF (F:)
mhhhhhhssgvdlgtenlyfqsmaqadialiglavmgqnlilnmndhgfvvcafnrtvsk
vddflaneakgtkvvgaqslkemvsklkkprriillvkagqavddfieklvplldtgdii
idggnseyrdttrrcrdlkakgilfvgsgvsggeegarygpslmpggnkeawphiktifq
giaakvgtgepccdwvgdegaghfvkmvhngieygdmqliceayhlmkdvlgmaqdemaq
afedwnkteldsflieitanilkfqdtdgkhllpkirdsagqkgtgkwtaisaleygvpv
tligeavfarclsslkderiqaskklkgpqkfqfdgdkksfledirkalyaskiisyaqg
fmllrqaatefgwtlnyggialmwrggciirsvflgkikdafdrnpelqnlllddffksa
vencqdswrravstgvqagipmpcfttalsfydgyrhemlpasliqaqrdyfgahtyell
akpgqfihtnwtghggtvssssyna

    Sequence, based on observed residues (ATOM records): (download) 
    >2jkvF (F:)
aqadialiglavmgqnlilnmndhgfvvcafnrtvskvddflaneakgtkvvgaqslkem
vsklkkprriillvkagqavddfieklvplldtgdiiidggnseyrdttrrcrdlkakgi
lfvgsgvsggeegarygpslmpggnkeawphiktifqgiaakvgtgepccdwvgdegagh
fvkmvhngieygdmqliceayhlmkdvlgmaqdemaqafedwnkteldsflieitanilk
fqdtdgkhllpkirdsagqkgtgkwtaisaleygvpvtligeavfarclsslkderiqas
kklkgpqkfqfdgdkksfledirkalyaskiisyaqgfmllrqaatefgwtlnyggialm
wrggciirsvflgkikdafdrnpelqnlllddffksavencqdswrravstgvqagipmp
cfttalsfydgyrhemlpasliqaqrdyfgahtyellakpgqfihtnwtgh