PDB entry 2j5f

View 2j5f on RCSB PDB site
Description: crystal structure of egfr kinase domain in complex with an irreversible inhibitor 34-jab
Class: transferase
Keywords: cell cycle, ATP-binding, transferase, polymorphism, irreversible inhibitor, tyrosine-protein kinase, egfr, kinase, 34-jab, membrane, receptor, wild-type, epidermal growth factor, anti-oncogene, transmembrane, nucleotide-binding, alternative splicing, ubl conjugation, phosphorylation, disease mutation, glycoprotein
Deposited on 2006-09-14, released 2007-02-27
The last revision prior to the SCOP 1.73 freeze date was dated 2007-07-17, with a file datestamp of 2007-07-13.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.194
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2j5fa1
  • Heterogens: DJK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2j5fA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >2j5fA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekvpikwmal
esilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidv
ymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsplmdeedmddvv
dadeylipq