SCOPe 2.06: Structural Classification of Proteins

PDB entry 2j5e

View 2j5e on RCSB PDB site
Description: crystal structure of egfr kinase domain in complex with an irreversible inhibitor 13-jab
Class: transferase
Keywords: cell cycle, ATP-binding, transferase, polymorphism, irreversible inhibitor, tyrosine-protein kinase, egfr, kinase, 13-jab, membrane, receptor, wild-type, epidermal growth factor, anti-oncogene, transmembrane, nucleotide-binding, alternative splicing, ubl conjugation, phosphorylation, disease mutation, glycoprotein
Deposited on 2006-09-14, released 2007-02-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.191
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P00533 (0-End)
Domains in SCOPe 2.06: d2j5ea_
Heterogens: CL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2j5eA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptds
nfyralmdeedmddvvdadeylipqqg

Sequence, based on observed residues (ATOM records): (download)

>2j5eA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggk
vpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpq
ppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdemhlpedmddv
vdadeylipq