PDB entry 2j0m

View 2j0m on RCSB PDB site
Description: Crystal structure a two-chain complex between the FERM and kinase domains of focal adhesion kinase.
Class: transferase
Keywords: focal adhesion, cell migration, phosphorylation, ferm, kinase, transferase, ATP-binding, integrin signaling, nucleotide-binding, tyrosine-protein kinase
Deposited on 2006-08-03, released 2007-07-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-12-04, with a file datestamp of 2013-11-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.224
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Focal adhesion kinase 1
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed):
    • PDB 2J0M
    • Uniprot Q00944 (2-End)
    Domains in SCOPe 2.05: d2j0ma1, d2j0ma2, d2j0ma3
  • Chain 'B':
    Compound: Focal adhesion kinase 1
    Species: Gallus gallus [TaxId:9031]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00944 (Start-275)
      • conflict (38)
      • conflict (105)
      • conflict (145-146)
    Domains in SCOPe 2.05: d2j0mb_
  • Heterogens: 4ST, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2j0mA (A:)
gsgamervlkvfhyfenssepttwasiirhgdatdvrgiiqkivdchkvknvacyglrls
hlqseevhwlhldmgvsnvrekfelahppeewkyelrirylpkgflnqftedkptlnffy
qqvkndymleiadqvdqeialklgcleirrsygemrgnalekksnyevlekdvglrrffp
kslldsvkaktlrkliqqtfrqfanlnreesilkffeilspvyrfdkecfkcalgsswii
svelaigpeegisyltdkganpthladfnqvqtiqysnsedkdrkgmlqlkiagapeplt
vtapsltiaenmadlidgycrlvngatqsfiirpqkegeralpsipklannekqgvrsht
vsvsetddyae

    Sequence, based on observed residues (ATOM records): (download) 
    >2j0mA (A:)
gamervlkvfhyfenssepttwasiirhgdatdvrgiiqkivdchkvknvacyglrlshl
qseevhwlhldmgvsnvrekfelahppeewkyelrirylpkgflnqftedkptlnffyqq
vkndymleiadqvdqeialklgcleirrsygemrgnalekksnyevlekdvglrrffpks
lldsvkaktlrkliqqtfrqfanlnreesilkffeilspvyrfdkecfkcalgsswiisv
elaigpeegisyltdkganpthladfnqvqtiqysnsedkdrkgmlqlkiagapepltvt
apsltiaenmadlidgycrlvngatqsfi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2j0mB (B:)
strdyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflq
ealtmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayql
stalayleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwma
pesinfrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncppt
lyslmtkcwaydpsrrprftelkaqlstileeeklq

    Sequence, based on observed residues (ATOM records): (download) 
    >2j0mB (B:)
dyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdfgllpikwmapesinfrrftsasdvwmfg
vcmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprf
telkaqlstileeeklq