PDB entry 2iw6

View 2iw6 on RCSB PDB site
Description: structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor
Class: cell cycle complex
Keywords: phosphorylation, nucleotide-binding, serine/threonine-protein kinase, cell cycle complex, kinase, cyclin, mitosis, cell cycle, transferase, ATP-binding, polymorphism, cell division, serine-threonine-protein kinase
Deposited on 2006-06-26, released 2006-09-06
The last revision prior to the SCOP 1.73 freeze date was dated 2006-09-06, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.23097
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • engineered mutation (92)
  • Chain 'B':
    Compound: Cyclin-A2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2iw6b1, d2iw6b2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (4-End)
      • engineered mutation (92)
  • Chain 'D':
    Compound: Cyclin-A2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2iw6d1, d2iw6d2
  • Heterogens: MG, QQ2, SGM, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2iw6B (B:)
mevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetl
hlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvl
rmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylp
sviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirek
yknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iw6B (B:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
agaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykn
skyhgvsllnppetlnl

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2iw6D (D:)
mevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetl
hlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvl
rmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylp
sviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirek
yknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2iw6D (D:)
yhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhlavn
yidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrmehl
vlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsviag
aafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyknsk
yhgvsllnppetlnl