PDB entry 2imb

View 2imb on RCSB PDB site
Description: Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by L-arginine hydroxamate
Class: hydrolase
Keywords: Clostridium botulinum neurotoxin serotype A, protease inhibitors, substrate specificity, substrate switching, HYDROLASE
Deposited on 2006-10-04, released 2007-06-05
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.41 Å
R-factor: 0.195
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Botulinum neurotoxin A light-chain
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7B8V4 (20-End)
      • cloning artifact (10-19)
      • conflict (21)
    Domains in SCOPe 2.04: d2imba_
  • Chain 'B':
    Compound: Botulinum neurotoxin A light-chain
    Species: Clostridium botulinum [TaxId:1491]
    Gene: botA, atx, bna
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7B8V4 (20-End)
      • cloning artifact (10-19)
      • conflict (21)
    Domains in SCOPe 2.04: d2imbb_
  • Heterogens: ZN, AHL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2imbA (A:)
mgsshhhhhhssglvprgshmqfvnkqfnykdpvngvdiayikipnvgqmqpvkafkihn
kiwviperdtftnpeegdlnpppeakqvpvsyydstylstdnekdnylkgvtklferiys
tdlgrmlltsivrgipfwggstidtelkvidtncinviqpdgsyrseelnlviigpsadi
iqfecksfghevlnltrngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavt
lahelihaghrlygiainpnrvfkvntnayyemsglevsfeelrtfgghdakfidslqen
efrlyyynkfkdiastlnkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdk
lykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaan
fngqnteinnmnftklknftglfe

    Sequence, based on observed residues (ATOM records): (download) 
    >2imbA (A:)
ssglvprgshmqfvnkqfnykdpvngvdiayikipvkafkihnkiwviperdtftnpeeg
dlnppvpvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwggst
idtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngygs
tqyirfspdftfgfeeslagkfatdpavtlahelihaghrlygiainpnrvfkevsfeel
rtfgghdakfidslqenefrlyyynkfkdiastlnkaksivgaslqymknvfkekyllse
dtsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnyt
iydgfnlrntnlaanfngqnteinnmnftklkn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2imbB (B:)
mgsshhhhhhssglvprgshmqfvnkqfnykdpvngvdiayikipnvgqmqpvkafkihn
kiwviperdtftnpeegdlnpppeakqvpvsyydstylstdnekdnylkgvtklferiys
tdlgrmlltsivrgipfwggstidtelkvidtncinviqpdgsyrseelnlviigpsadi
iqfecksfghevlnltrngygstqyirfspdftfgfeeslevdtnpllgagkfatdpavt
lahelihaghrlygiainpnrvfkvntnayyemsglevsfeelrtfgghdakfidslqen
efrlyyynkfkdiastlnkaksivgttaslqymknvfkekyllsedtsgkfsvdklkfdk
lykmlteiytednfvkffkvlnrktylnfdkavfkinivpkvnytiydgfnlrntnlaan
fngqnteinnmnftklknftglfe

    Sequence, based on observed residues (ATOM records): (download) 
    >2imbB (B:)
ssglvprgshmqfvnkqfnykdpvngvdiayikipnmqpvkafkihnkiwviperdtftn
peegdlnppvsyydstylstdnekdnylkgvtklferiystdlgrmlltsivrgipfwgg
stidtelkvidtncinviqpdgsyrseelnlviigpsadiiqfecksfghevlnltrngy
gstqyirfspdftfgfeeslevdtnpllgagkfatdpavtlahelihaghrlygiainpn
rvevsfeelrtfgghdakfidslqenefrlyyynkfkdiastlnkaksivgttaslqymk
nvfkekyllsedtsgkfsvdklkfdklykmlteiytednfvkffkvlnrktylnfdkavf
kinivpkvnytiydgfnlrntnlaanfngqnteinnmnftkl