PDB entry 2ilt

View 2ilt on RCSB PDB site
Description: Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor
Class: oxidoreductase
Keywords: HSD1, NADP, inhibitor, OXIDOREDUCTASE
Deposited on 2006-10-03, released 2007-04-03
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.212
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD11B1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28845 (13-274)
      • cloning artifact (0-12)
      • conflict (261)
    Domains in SCOPe 2.01: d2ilta_
  • Heterogens: NI, NAP, NN1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2iltA (A:)
qhqhqhqhqhqqpneefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsket
lqkvvshclelgaasahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfh
ddihhvrksmevnflsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfal
dgffssirkeysvsrvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikgga
lrqeevyydsslwttllirnpsrkileflystsyn