PDB entry 2i4h

View 2i4h on RCSB PDB site
Description: Structural studies of protein tyrosine phosphatase beta catalytic domain co-crystallized with a sulfamic acid inhibitor
Class: hydrolase
Keywords: protein tyrosine phosphatase, WPD-loop, sulfamic acid, phosphatase, inhibitor, drug design, HYDROLASE
Deposited on 2006-08-21, released 2006-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.17
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-type tyrosine-protein phosphatase beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPRB, PTPB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2i4ha_
  • Heterogens: MG, CL, UA1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2i4hA (A:)
sdrplsvhlnlgqkgnrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscd
iallpenrgknrynnilpydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplp
gtkddfwkmvweqnvhnivmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpe
wtirefkicgeeqldahrlirhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagpt
vvhcsagvgrtgtfialdrilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcv
rdvlrarklrseq

    Sequence, based on observed residues (ATOM records): (download) 
    >2i4hA (A:)
ktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynnil
pydatrvklscsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhnivmvtq
cvekgrvkcdhywpadqdslyygdlilqmlsesvlpewtirefkichrlirhfhytvwpd
hgvpettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdrilqqldskdsv
diygavhdlrlhrvhmvqtecqyvylhqcvrdvlrarklr