PDB entry 2i3u
View 2i3u on RCSB PDB site
Description: Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Class: hydrolase
Keywords: protein tyrosine phosphatase, WPD-loop, sulfamic acid, phosphatase, inhibitor, drug design, HYDROLASE
Deposited on
2006-08-20, released
2006-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.187
AEROSPACI score: 0.48
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Receptor-type tyrosine-protein phosphatase beta
Species: Homo sapiens [TaxId:9606]
Gene: PTPRB, PTPB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2i3ua_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2i3uA (A:)
sdrplsvhlnlgqkgnrktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscd
iallpenrgknrynnilpydatrvklsnvdddpcsdyinasyipgnnfrreyivtqgplp
gtkddfwkmvweqnvhnivmvtqcvekgrvkcdhywpadqdslyygdlilqmlsesvlpe
wtirefkicgeeqldahrlirhfhytvwpdhgvpettqsliqfvrtvrdyinrspgagpt
vvhcsagvgrtgtfialdrilqqldskdsvdiygavhdlrlhrvhmvqtecqyvylhqcv
rdvlrarklrseq
Sequence, based on observed residues (ATOM records): (download)
>2i3uA (A:)
ktscpikinqfeghfmklqadsnyllskeyeelkdvgrnqscdiallpenrgknrynnil
pydatrvklsnsdyinasyipgnnfrreyivtqgplpgtkddfwkmvweqnvhnivmvth
ywpadqdslyygdlilqmlsesvlpewtirefkicgeeqldahrlirhfhytvwpdhgvp
ettqsliqfvrtvrdyinrspgagptvvhcsagvgrtgtfialdrilqqldskdsvdiyg
avhdlrlhrvhmvqtecqyvylhqcvrdvlrarklr