PDB entry 2hz0

View 2hz0 on RCSB PDB site
Description: Abl kinase domain in complex with NVP-AEG082
Class: Transferase
Keywords: tyrosine kinase, Transferase
Deposited on 2006-08-08, released 2007-01-16
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.195
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2hz0a_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2hz0b_
  • Heterogens: GIN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2hz0A (A:)
    vspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
    avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqi
    ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
    peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
    vyelmracwqwnpsdrpsfaeihqafetmf
    

    Sequence, based on observed residues (ATOM records): (download)
    >2hz0A (A:)
    dkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke
    ikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissame
    ylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapesla
    ynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelm
    racwqwnpsdrpsfaeihqafetmf
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2hz0B (B:)
    vspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
    avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqi
    ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
    peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
    vyelmracwqwnpsdrpsfaeihqafetmf
    

    Sequence, based on observed residues (ATOM records): (download)
    >2hz0B (B:)
    vspnydkwemertditmkhklevyegvwkkysltvavktlmeveeflkeaavmkeikhpn
    lvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameylekk
    nfihrdlaarnclvgenhlvkvadfglpikwtapeslaynkfsiksdvwafgvllweiat
    ygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaeihqafe
    tmf