PDB entry 2hyy

View 2hyy on RCSB PDB site
Description: Human Abl kinase domain in complex with imatinib (STI571, Glivec)
Class: transferase
Keywords: Tyrosine kinase, TRANSFERASE
Deposited on 2006-08-08, released 2007-01-16
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.204
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2hyya_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2hyyb_
  • Chain 'C':
    Compound: Proto-oncogene tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2hyyc_
  • Chain 'D':
    Compound: Proto-oncogene tyrosine-protein kinase ABL1
    Species: Homo sapiens [TaxId:9606]
    Gene: ABL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d2hyyd_
  • Heterogens: STI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hyyA (A:)
vspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqes

    Sequence, based on observed residues (ATOM records): (download) 
    >2hyyA (A:)
wemertditmkhklgggqygevyegvwkkysltvavktlkdtmeveeflkeaavmkeikh
pnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameyle
kknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynk
fsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmrac
wqwnpsdrpsfaeihqafetmfq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hyyB (B:)
vspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqes

    Sequence, based on observed residues (ATOM records): (download) 
    >2hyyB (B:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlketmeveeflkeaavmkei
khpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissamey
lekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslay
nkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmr
acwqwnpsdrpsfaeihqafetmfq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2hyyC (C:)
vspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqes

    Sequence, based on observed residues (ATOM records): (download) 
    >2hyyC (C:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlketmeveeflkeaavmkei
khpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissamey
lekknfihrdlaarnclvgenhlvkvadfglsrlmtytahagakfpikwtapeslaynkf
siksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracw
qwnpsdrpsfaeihqafetmfq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2hyyD (D:)
vspnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkea
avmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqi
ssameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwta
peslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpek
vyelmracwqwnpsdrpsfaeihqafetmfqes

    Sequence, based on observed residues (ATOM records): (download) 
    >2hyyD (D:)
dkwemertditmkhklgggqygevyegvwkkysltvavktlkemeveeflkeaavmkeik
hpnlvqllgvctreppfyiitefmtygnlldylrecnrqevnavvllymatqissameyl
ekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslayn
kfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmra
cwqwnpsdrpsfaeihqafetmfq