PDB entry 2hwo

View 2hwo on RCSB PDB site
Description: Crystal structure of Src kinase domain in complex with covalent inhibitor
Class: transferase
Keywords: kinase, covalent, quinazoline, modification, transferase
Deposited on 2006-08-01, released 2007-02-27
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.238
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered (97)
    Domains in SCOPe 2.04: d2hwoa_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-285)
      • engineered (97)
    Domains in SCOPe 2.04: d2hwob_
  • Heterogens: RBS, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hwoA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2hwoA (A:)
lakdaweipreslrlevklggcfgevwmgtwngttrvaiktlkpflqeaqvmkklrhekl
vqlyavvspiyivteymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvh
rdlraanilvgenlvckvadfgpikwtapeaalygrftiksdvwsfgilltelttkgrvp
ypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyfts
tepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hwoB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgclldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >2hwoB (B:)
daweipreslrlevklgqggevwmgtwngttrvaiktlkqvmkklrheklvqlyavvsee
piyivteymskgclldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraani
lvgenlvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrev
ldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpge
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