PDB entry 2huw

View 2huw on RCSB PDB site
Description: X-ray crystal structure of the Grb2 SH2 domain complexed to a constrained and cyclopropane-derived ligand
Class: hormone/growth factor
Keywords: cylcopropane, contrained, Grb2, SH2, preorganization,
Deposited on 2006-07-27, released 2006-08-15
The last revision prior to the SCOP 1.75 freeze date was dated 2006-10-31, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.195
AEROSPACI score: 0.63 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Growth factor receptor-bound protein 2
    Species: HOMO SAPIENS
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2huwa1
  • Chain 'B':
    Compound: Growth factor receptor-bound protein 2
    Species: HOMO SAPIENS
    Gene: GRB2, ASH
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2huwb1
  • Heterogens: PO4, YVN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2huwA (A:)
iemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlr
dgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2huwA (A:)
mkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdg
agkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2huwB (B:)
iemkphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlr
dgagkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieqvpqqptyvqhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2huwB (B:)
kphpwffgkiprakaeemlskqrhdgafliresesapgdfslsvkfgndvqhfkvlrdga
gkyflwvvkfnslnelvdyhrstsvsrnqqiflrdieq