PDB entry 2hs2
View 2hs2 on RCSB PDB site
Description: Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)
Class: hydrolase
Keywords: aspartic protease active site surface binding site, HYDROLASE
Deposited on
2006-07-20, released
2006-10-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-25.
Experiment type: XRAY
Resolution: 1.22 Å
R-factor: 0.142
AEROSPACI score: 0.83
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Protease
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: GAG
Database cross-references and differences (RAF-indexed):
- Uniprot P03368
- engineered (6)
- engineered (32)
- engineered (45)
- engineered (62)
- engineered (66)
- engineered (94)
Domains in SCOPe 2.08: d2hs2a_ - Chain 'B':
Compound: Protease
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: GAG
Database cross-references and differences (RAF-indexed):
- Uniprot P03368 (0-98)
- engineered (6)
- engineered (32)
- engineered (45)
- engineered (62)
- engineered (66)
- engineered (94)
Domains in SCOPe 2.08: d2hs2b_ - Heterogens: CL, 017, DMS, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2hs2A (A:)
pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkliggiggfikvrqyd
qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>2hs2B (B:)
pqitlwkrplvtikiggqlkealldtgaddtvieemslpgrwkpkliggiggfikvrqyd
qiiieiaghkaigtvlvgptpvniigrnlltqigatlnf