PDB entry 2hny

View 2hny on RCSB PDB site
Description: Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, nevirapine, drug resistance mutations, drug design, transferase
Deposited on 2006-07-13, released 2006-09-05
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.214
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-533)
      • engineered (134)
      • modified residue (276)
    Domains in SCOPe 2.06: d2hnya1, d2hnya2
  • Chain 'B':
    Compound: Reverse transcriptase/ribonuclease H
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-421)
      • engineered (131)
    Domains in SCOPe 2.06: d2hnyb_
  • Heterogens: PO4, MG, NVP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2hnyA (A:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
frkytaftipsinnktpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiy
lalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp

    Sequence, based on observed residues (ATOM records): (download) 
    >2hnyA (A:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
frkytaftipsinnktpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyqlekepivgaetfyvdagyvtnrgrqkvvtltdttnqktelqaiylalqdsglevn
ivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2hnyB (B:)
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnktpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
yq

    Sequence, based on observed residues (ATOM records): (download) 
    >2hnyB (B:)
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwphpaglkkkksvtvldvgdayfsvpldedfrkytafti
psinnktpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsd
leigqhrtkieelrqhllrwkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvg
klnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydps
kdliaeiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktp
kfklpiqketwetwwteywqatwipewefvntpplvklwyq