PDB entry 2h6h

View 2h6h on RCSB PDB site
Description: Y365F Protein Farnesyltransferase Mutant Complexed with a Farnesylated DDPTASACVLS Peptide Product at 1.8A
Class: transferase
Keywords: FTase, farnesyltransferase, farnesyl transferase, prenyltransferase, CaaX, Ras, lipid modification, prenylation, substrate selectivity
Deposited on 2006-05-31, released 2006-08-29
The last revision prior to the SCOP 1.73 freeze date was dated 2006-08-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.177
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
    Species: HOMO SAPIENS
    Gene: Human FTase alpha subunit
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2h6ha1
  • Chain 'B':
    Compound: Protein farnesyltransferase beta subunit
    Species: HOMO SAPIENS
    Gene: Human FTase beta subunit
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49356
      • engineered (364)
  • Chain 'P':
    Compound: farnesylated peptide
    Species: synthetic, synthetic
  • Heterogens: SUC, ZN, FAR, ACY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2h6hA (A:)
maategvgeaaqggepgqpaqpppqphppppqqqhkeemaaeageavaspmddgfvslds
psyvlyrdraewadidpvpqndgpnpvvqiiysdkfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllkslqkdlheemnyitaiieeqpknyqvwhhrrvlvewlr
dpsqelefiadilnqdaknyhawqhrqwviqefklwdnelqyvdqllkedvrnnsvwnqr
yfvisnttgyndravlerevqytlemiklvphnesawnylkgilqdrglskypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhstendsptnvqqeef

    Sequence, based on observed residues (ATOM records): (download) 
    >2h6hA (A:)
fvsldspsyvlyrdraewadidpvpqndgpnpvvqiiysdkfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllkslqkdlheemnyitaiieeqpknyqvwhhrrv
lvewlrdpsqelefiadilnqdaknyhawqhrqwviqefklwdnelqyvdqllkedvrnn
svwnqryfvisnttgyndravlerevqytlemiklvphnesawnylkgilqdrglskypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhst

  • Chain 'B':
    No sequence available.

  • Chain 'P':
    No sequence available.