PDB entry 2gtw

View 2gtw on RCSB PDB site
Description: Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution
Class: immune system
Keywords: Melan-A/MART-1 peptide, nonapeptide, MHC class I, HLA-A2, A27L mutation, melanoma, cancer vaccines, IMMUNE SYSTEM
Deposited on 2006-04-28, released 2007-06-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: 0.183
AEROSPACI score: 0.61 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: HLA-A*0201 heavy chain
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-A
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9TQH5 (0-274)
  Domains in SCOPe 2.06: d2gtwa1, d2gtwa2
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.06: d2gtwb2, d2gtwb3
• Chain 'C':
  Compound: octapeptide from Melan-A/MART-1
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q16655 (1-8)
    • engineered (0)
• Chain 'D':
  Compound: HLA-A*0201 heavy chain
  Species: Homo sapiens [TaxId:9606]
  Gene: HLA-A
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9TQH5 (0-274)
  Domains in SCOPe 2.06: d2gtwd1, d2gtwd2
• Chain 'E':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.06: d2gtwe2, d2gtwe3
• Chain 'F':
  Compound: octapeptide from Melan-A/MART-1
  Species: synthetic, synthetic
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q16655 (1-8)
    • engineered (0)
• Heterogens: NA, GOL, FMT, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2gtwA (A:)
  gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
  dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
  kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
  rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
  fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2gtwB (B:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2gtwD (D:)
  gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
  dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
  kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
  rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
  fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
  

  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2gtwE (E:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'F':
  No sequence available.