PDB entry 2gtw

View 2gtw on RCSB PDB site
Description: Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution
Class: immune system
Keywords: X-ray crystallography, Melan-A/MART-1 peptide, nonapeptide, MHC class I, HLA-A2, A27L mutation, melanoma, cancer vaccines
Deposited on 2006-04-28, released 2007-06-12
The last revision prior to the SCOP 1.75 freeze date was dated 2007-10-02, with a file datestamp of 2007-09-28.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: 0.183
AEROSPACI score: 0.73 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA-A*0201 heavy chain
    Species: HOMO SAPIENS
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2gtwa1, d2gtwa2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: HOMO SAPIENS
    Gene: B2M
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOP 1.75: d2gtwb1
  • Chain 'C':
    Compound: octapeptide from Melan-A/MART-1
    Species: synthetic, synthetic
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16655 (1-8)
      • engineered (0)
  • Chain 'D':
    Compound: HLA-A*0201 heavy chain
    Species: HOMO SAPIENS
    Gene: HLA-A
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2gtwd1, d2gtwd2
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: HOMO SAPIENS
    Gene: B2M
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOP 1.75: d2gtwe1
  • Chain 'F':
    Compound: octapeptide from Melan-A/MART-1
    Species: synthetic, synthetic
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16655 (1-8)
      • engineered (0)
  • Heterogens: NA, GOL, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2gtwA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2gtwB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2gtwD (D:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2gtwE (E:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'F':
    No sequence available.