PDB entry 2geb

View 2geb on RCSB PDB site
Description: Crystal structure of the Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyltransferase L160I mutant: insights into the inhibitor design
Class: transferase
Keywords: HGPRT, mutant, inhibitor design, selectivity, TRANSFERASE
Deposited on 2006-03-19, released 2007-04-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.204
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hypoxanthine-guanine phosphoribosyltransferase
    Species: Thermoanaerobacter tengcongensis [TaxId:119072]
    Gene: HGPRT, Hpt
    Database cross-references and differences (RAF-indexed):
    • GB AAM25533 (4-End)
      • expression tag (0-3)
      • engineered (56)
      • engineered (70)
      • engineered (163)
    Domains in SCOPe 2.08: d2geba1, d2geba2
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2gebA (A:)
rgshmpspmedieeiliteeqlkakvkelgemitrdyegkdlvligvlkgaimfmsglsr
aidlplsidflavssygsstkssgivkiikdhdidiegkdvlivediidsgltlaylret
llgrkprslkictildkperreadvkvdycgfkipdkfvvgygidyaekyrnlpfigvlk
pelyk

    Sequence, based on observed residues (ATOM records): (download) 
    >2gebA (A:)
rgshmpspmedieeiliteeqlkakvkelgemitrdyegkdlvligvlkgaimfmsglsr
aidlplsidflavssygsstkssgivkiikdhdidiegkdvlivediidsgltlaylret
llgrkprslkictildkperreadvkvdycgfkipdkfvvgygidyaekyrnlpfigvlk
pely