PDB entry 2g9x

View 2g9x on RCSB PDB site
Description: Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271
Class: transferase/Cell cycle
Keywords: transferase, serine/threonine protein kinase, ATP-binding, cell cycle, phosphorylation
Deposited on 2006-03-07, released 2006-05-23
The last revision prior to the SCOP 1.75 freeze date was dated 2006-05-23, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.219
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: HOMO SAPIENS
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-298)
      • cloning artifact (0)
      • modified residue (160)
    Domains in SCOP 1.75: d2g9xa1
  • Chain 'B':
    Compound: Cyclin-A2
    Species: BOS TAURUS
    Gene: CCNA2, CCNA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30274 (1-261)
      • cloning artifact (0)
      • see remark 999 (261)
    Domains in SCOP 1.75: d2g9xb1, d2g9xb2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: HOMO SAPIENS
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-298)
      • cloning artifact (0)
      • modified residue (160)
    Domains in SCOP 1.75: d2g9xc1
  • Chain 'D':
    Compound: Cyclin-A2
    Species: BOS TAURUS
    Gene: CCNA2, CCNA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30274 (1-261)
      • cloning artifact (0)
      • see remark 999 (261)
    Domains in SCOP 1.75: d2g9xd1, d2g9xd2
  • Heterogens: NU5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2g9xA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2g9xB (B:)
gvnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2g9xC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >2g9xC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdfskvvppldedgrsll
sqmlhydpnkrisakaalahpffqdvtkpvphlrl

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2g9xD (D:)
gvnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnl