PDB entry 2g8j
View 2g8j on RCSB PDB site
Description: Calpain 1 proteolytic core in complex with SNJ-1945, a alpha-ketoamide-type inhibitor.
Class: hydrolase
Keywords: protease, peptidase, inhibitor, alpha-ketoamide
Deposited on
2006-03-02, released
2006-06-06
The last revision prior to the SCOP 1.75 freeze date was dated
2006-06-20, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 1.61 Å
R-factor: 0.198
AEROSPACI score: 0.65
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Calpain-1 catalytic subunit
Species: Rattus norvegicus
Gene: Capn1, Cls1
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d2g8ja1 - Heterogens: CA, D7G, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2g8jA (A:)
mglgrhenaikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikw
krptellsnpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegy
agifhfqlwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyeal
sggctseafedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitf
knlvrghaysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereql
rvkmedgefwmsfrdfireftkleicnltpdlehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2g8jA (A:)
naikylgqdyenlrarclqngvlfqddafppvshslgfkelgpnssktygikwkrptell
snpqfivdgatrtdicqgalgdcwllaaiasltlnetilhrvvpygqsfqegyagifhfq
lwqfgewvdvvvddllptkdgklvfvhsaqgnefwsallekayakvngsyealsggctse
afedftggvtewydlqkapsdlyqiilkalergsllgcsinisdirdleaitfknlvrgh
aysvtdakqvtyqgqrvnlirmrnpwgevewkgpwsdnsyewnkvdpyereqlrvkmedg
efwmsfrdfireftkleicnlt