PDB entry 2fwy
View 2fwy on RCSB PDB site
Description: Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64
Class: chaperone
Keywords: HSP90, GRP94, chaperone, purine, PU3, H64, H71
Deposited on
2006-02-03, released
2006-10-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.181
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Heat shock protein HSP 90-alpha
Species: Homo sapiens [TaxId:9606]
Gene: HSPCA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2fwya_ - Heterogens: H64, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2fwyA (A:)
mgsshhhhhhssglvprgshmpeetqtqdqpmeeeevetfafqaeiaqlmsliintfysn
keiflrelisnssdaldkiryesltdpskldsgkelhinlipnkqdrtltivdtgigmtk
adlinnlgtiaksgtkafmealqagadismigqfgvgfysaylvaekvtvitkhnddeqy
awessaggsftvrtdtgepmgrgtkvilhlkedqteyleerrikeivkkhsqfigypitl
fvekerdkevsddeae
Sequence, based on observed residues (ATOM records): (download)
>2fwyA (A:)
vetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgkel
hinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfgv
gfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqte
yleerrikeivkkhsqfigypitlfve